Version 5.4
Homo sapiens Gene: SSR4
Summary
InnateDB Gene IDBG-90038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSR4
Gene Name signal sequence receptor, delta
Synonyms TRAPD
Species Homo sapiens
Ensembl Gene ENSG00000180879
Encoded Proteins
IDBP-90040
signal sequence receptor, delta
IDBP-90042
signal sequence receptor, delta
IDBP-90044
signal sequence receptor, delta
IDBP-90046
signal sequence receptor, delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153793516-153798505
Strand Forward strand
Band q28
Transcripts
ENST00000320857 ENSP00000317331
ENST00000370087 ENSP00000359104
ENST00000370086 ENSP00000359103
ENST00000370085 ENSP00000359102
ENST00000447375
ENST00000491833
ENST00000482902
ENST00000460616
ENST00000471724
ENST00000471880
ENST00000486204
ENST00000485612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006412 translation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005784 Sec61 translocon complex
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002014
View Gene Order
ENSBTAG00000021421
Not yet available
Pathways
NETPATH
REACTOME
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.409223
RefSeq NM_001204526 NM_001204527 NM_006280
HUGO
OMIM
CCDS CCDS14731
HPRD 02101
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca