Version 5.4
Homo sapiens Gene: PGK2
Summary
InnateDB Gene IDBG-90293.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGK2
Gene Name phosphoglycerate kinase 2
Synonyms dJ417L20.2; HEL-S-272; PGKB; PGKPS
Species Homo sapiens
Ensembl Gene ENSG00000170950
Encoded Proteins
IDBP-90295
phosphoglycerate kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:49785934-49787187
Strand Reverse strand
Band p12.3
Transcripts
ENST00000304801 ENSP00000305995
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004618 phosphoglycerate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0030317 sperm motility
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005929 cilium
GO:0035686 sperm fibrous sheath
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
PID NCI
Cross-References
SwissProt P07205
TrEMBL
UniProt Splice Variant
Entrez Gene 5232
UniGene Hs.367727
RefSeq NM_138733
HUGO HGNC:8898
OMIM 172270
CCDS CCDS4930
HPRD
IMGT
EMBL AK312770 AL121974 BC038843 X05246
GenPept AAH38843 BAG35635 CAA28872 CAC19655
RNA Seq Atlas 5232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca