InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL17A

Summary

InnateDB Gene

IDBG-90504.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL17A

Gene Name

interleukin 17A

Synonyms

CTLA8; IL-17; IL-17A; IL17

Species

Homo sapiens

Ensembl Gene

ENSG00000112115

Encoded Proteins

IDBP-90506

interleukin 17A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19144317

IL17A is a cytokine produced by T helper 17 (Th17) cells that plays important roles in the development of inflammatory diseases.

PMID 20083670

IL17A is an innate-adaptive immunomodulatory cytokine that is produced by gammadelta cells and is a key mediator for the innate immune response to urinary tract infections (UTIs) caused by uropathogenic Escherichia coli.

PMID 21074482

IL17A is a Th17-related cytokine, traditionally thought of as an adaptive responder, has been shown to have various innate sources and functions as a rapidly produced pro-inflammatory mediator. Innate IL17A-producing cells also employ many of the cytokine and transcriptional regulators utilized by Th17 cells.

PMID 21822258

IL17A signalling enhances the mRNA stability of chemokine CXCL1 through TRAF3IP2, TRAF2-TRAF5 and the RNA-binding protein SRSF1.

PMID 22384827

IL17A is significantly upregulated in both S. pyogenes inoculated and mock inoculated mice, indicating that the cytokine production can be triggered by inoculation trauma alone. (Demonstrated in mice)

PMID 24194936

Local production of IL17A in the airways drives early neutrophil infiltration into respiratory syncytial virus infected infant lungs.

PMID 25474109

IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.

InnateDB Annotation from Orthologs

Summary

PMID 21822258

[Mus musculus] Il17a signalling enhances the mRNA stability of chemokine Cxcl1 through Traf3ip2, Traf2-Traf5 and the RNA-binding protein Srsf1.

PMID 22384827

[Mus musculus] Il17a is significantly upregulated in both S. pyogenes inoculated and mock inoculated mice, indicating that the cytokine production can be triggered by inoculation trauma alone.

PMID 23295184

[Mus musculus] IL17A inhibits the release of IL23 during pulmonary inflammation and serves as part of negative feedback loop to control antibacterial immunity.

PMID 24337746

[Mus musculus] Il17a is an intrinsic regulator in coordinating neutrophil and macrophage antimicrobial activity to provide protection against acute pneumonic plague.

PMID 24670684

[Mus musculus] In mouse model of leukocyte adhesion deficiency type I disease, defective neutrophil recruitment is associated with dysregulated local overproduction of IL17, which drives inflammatory periodontal bone loss.

PMID 25595775

[Mus musculus] Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.

PMID 26488187

[Mus musculus] Il17a is rapidly produced during lung injury and significantly contributes to early immunopathogenesis, a process that is orchestrated largely by a distinct population of pulmonary type 3 innate lymphoid cells.

Entrez Gene

Summary

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:52186387-52190638

Strand

Forward strand

Band

p12.2

Transcripts

ENST00000340057

ENSP00000344192

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0006486	protein glycosylation
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007267	cell-cell signaling
GO:0008219	cell death
GO:0032747	positive regulation of interleukin-23 production
GO:0045087	innate immune response (InnateDB)
GO:0045672	positive regulation of osteoclast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071347	cellular response to interleukin-1
GO:0072537	fibroblast activation
GO:1900017	positive regulation of cytokine production involved in inflammatory response

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0009897	external side of plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025929

View Gene Order

ENSBTAG00000002150

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

INOH website

GPCR signaling pathway

PID NCI

il27pathway

IL27-mediated signaling events

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.41724

RefSeq

NM_002190

HUGO

OMIM

CCDS

CCDS4937

HPRD

04396

IMGT

EMBL

GenPept

RNA Seq Atlas