Homo sapiens Gene: CEL
Summary
InnateDB Gene IDBG-90630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEL
Gene Name carboxyl ester lipase (bile salt-stimulated lipase)
Synonyms BAL; BSDL; BSSL; CEase; CELL; FAP; FAPP; LIPA; MODY8;
Species Homo sapiens
Ensembl Gene ENSG00000170835
Encoded Proteins
carboxyl ester lipase (bile salt-stimulated lipase)
carboxyl ester lipase (bile salt-stimulated lipase)
carboxyl ester lipase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:133061978-133087355
Strand Forward strand
Band q34.13
Transcripts
ENST00000372080 ENSP00000361151
ENST00000351304 ENSP00000342217
ENST00000621209 ENSP00000480238
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004771 sterol esterase activity
GO:0004806 triglyceride lipase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016787 hydrolase activity
GO:0047372 acylglycerol lipase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006707 cholesterol catabolic process
GO:0008152 metabolic process
GO:0009062 fatty acid catabolic process
GO:0018350 protein esterification
GO:0030157 pancreatic juice secretion
GO:0030299 intestinal cholesterol absorption
GO:0044241 lipid digestion
GO:0044258 intestinal lipid catabolic process
GO:0044281 small molecule metabolic process
GO:0046514 ceramide catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Digestion of dietary lipid pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
KEGG
Steroid biosynthesis pathway
Glycerolipid metabolism pathway
Pancreatic secretion pathway
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q14018
UniProt Splice Variant
Entrez Gene 1056
UniGene
RefSeq NM_001807
HUGO HGNC:1848
OMIM 114840
CCDS CCDS43896
HPRD
IMGT
EMBL CH471090 L14813
GenPept AAA16357 EAW88030
RNA Seq Atlas 1056