Homo sapiens Gene: RALGDS
Summary
InnateDB Gene IDBG-90728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RALGDS
Gene Name ral guanine nucleotide dissociation stimulator
Synonyms RalGEF; RGDS; RGF;
Species Homo sapiens
Ensembl Gene ENSG00000160271
Encoded Proteins
ral guanine nucleotide dissociation stimulator
ral guanine nucleotide dissociation stimulator
ral guanine nucleotide dissociation stimulator
ral guanine nucleotide dissociation stimulator
ral guanine nucleotide dissociation stimulator
ral guanine nucleotide dissociation stimulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:133097720-133149334
Strand Reverse strand
Band q34.2
Transcripts
ENST00000372062 ENSP00000361132
ENST00000372050 ENSP00000361120
ENST00000372047 ENSP00000361117
ENST00000393160 ENSP00000376867
ENST00000393157 ENSP00000376864
ENST00000424572 ENSP00000391814
ENST00000493438
ENST00000482648
ENST00000469972
ENST00000498797
ENST00000495621
ENST00000477660
ENST00000471109
ENST00000493067
ENST00000460587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050790 regulation of catalytic activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TSH pathway
REACTOME
Signalling by NGF pathway
p38MAPK events pathway
Signal Transduction pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Signalling to RAS pathway
KEGG
Pathways in cancer pathway
Colorectal cancer pathway
Pancreatic cancer pathway
INOH
PID BIOCARTA
Ras signaling pathway [Biocarta view]
PID NCI
ErbB1 downstream signaling
Cross-References
SwissProt Q12967
TrEMBL Q8N4Y1 Q8WU11 Q9HAX8 Q9HAX9 Q9HAY0
UniProt Splice Variant
Entrez Gene 5900
UniGene Hs.106185
RefSeq NM_001271776 NM_001042368 NM_001271774 NM_001271775 NM_006266
HUGO HGNC:9842
OMIM 601619
CCDS CCDS65172 CCDS43897 CCDS65173 CCDS65174 CCDS6959
HPRD 03371
IMGT
EMBL AB037729 AF027169 AF295773 AF295775 AF295776 AF295777 AF295778 AF295779 AF295780 AK127524 AK301470 AL162417 BC021581 BC033198 BC059362 CH471090 U14417
GenPept AAA52360 AAG02122 AAG10221 AAG10222 AAG10223 AAG10224 AAG10225 AAH21581 AAH33198 AAH59362 AAQ13414 BAA92546 BAC87018 BAH13489 CAI13415 CAI13417 EAW88040 EAW88042
RNA Seq Atlas 5900