Homo sapiens Gene: EIF3A
Summary
InnateDB Gene IDBG-90993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3A
Gene Name eukaryotic translation initiation factor 3, subunit A
Synonyms EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167; p180; p185; TIF32;
Species Homo sapiens
Ensembl Gene ENSG00000107581
Encoded Proteins
eukaryotic translation initiation factor 3, subunit A
eukaryotic translation initiation factor 3, subunit A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:119033670-119080823
Strand Reverse strand
Band q26.11
Transcripts
ENST00000369144 ENSP00000358140
ENST00000462527
ENST00000541549 ENSP00000438178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 139 [view]
Protein-Protein 138 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0001732 formation of translation initiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Formation of a pool of free 40S subunits pathway
Translation pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
Internal ribosome entry pathway [Biocarta view]
Eukaryotic protein translation [Biocarta view]
Mtor signaling pathway [Biocarta view]
PID NCI
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523299 Hs.605512 Hs.657236 Hs.713331
RefSeq NM_003750
HUGO
OMIM
CCDS CCDS7608
HPRD 03618
IMGT
EMBL
GenPept
RNA Seq Atlas