Homo sapiens Gene: G6PD
Summary
InnateDB Gene IDBG-91750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol G6PD
Gene Name glucose-6-phosphate dehydrogenase
Synonyms G6PD1;
Species Homo sapiens
Ensembl Gene ENSG00000160211
Encoded Proteins
glucose-6-phosphate dehydrogenase
glucose-6-phosphate dehydrogenase
glucose-6-phosphate dehydrogenase
glucose-6-phosphate dehydrogenase
glucose-6-phosphate dehydrogenase
glucose-6-phosphate dehydrogenase
glucose-6-phosphate dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:154531391-154547572
Strand Reverse strand
Band q28
Transcripts
ENST00000369620 ENSP00000358633
ENST00000393564 ENSP00000377194
ENST00000393562 ENSP00000377192
ENST00000439227 ENSP00000395599
ENST00000440967 ENSP00000400648
ENST00000433845 ENSP00000394690
ENST00000490651
ENST00000489497
ENST00000497281
ENST00000488434
ENST00000621232 ENSP00000483686
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 42 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004345 glucose-6-phosphate dehydrogenase activity
GO:0005515 protein binding
GO:0005536 glucose binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0050661 NADP binding
Biological Process
GO:0001816 cytokine production
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006098 pentose-phosphate shunt
GO:0006629 lipid metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0006739 NADP metabolic process
GO:0006740 NADPH regeneration
GO:0006749 glutathione metabolic process
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0010734 negative regulation of protein glutathionylation
GO:0014070 response to organic cyclic compound
GO:0019322 pentose biosynthetic process
GO:0021762 substantia nigra development
GO:0032094 response to food
GO:0034599 cellular response to oxidative stress
GO:0043249 erythrocyte maturation
GO:0043523 regulation of neuron apoptotic process
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0046390 ribose phosphate biosynthetic process
GO:0051156 glucose 6-phosphate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
Pentose phosphate pathway (hexose monophosphate shunt) pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
Disease pathway
Glycogen storage diseases pathway
KEGG
Pentose phosphate pathway pathway
Glutathione metabolism pathway
INOH
Pentose phosphate cycle pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.461047 Hs.684904
RefSeq NM_000402 NM_001042351 XM_005274657 XM_005274658
HUGO
OMIM
CCDS CCDS14756 CCDS44023
HPRD 02377
IMGT
EMBL
GenPept
RNA Seq Atlas