Homo sapiens Gene: GPSM1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-92256.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GPSM1 | ||||||||||||||||||
Gene Name | G-protein signaling modulator 1 | ||||||||||||||||||
Synonyms | AGS3 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000160360 | ||||||||||||||||||
Encoded Proteins |
G-protein signaling modulator 1
G-protein signaling modulator 1
G-protein signaling modulator 1
G-protein signaling modulator 1
G-protein signaling modulator 1
G-protein signaling modulator 1
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
GPSM1, an inhibitor of GNAI3, plays a key role in regulating autophagy; the dynamic interplay between GNAI3, GPSM1, and CCDC88A determines whether autophagy is promoted or inhibited. During starving conditions, GPSM1 binds to GNAI3 in MAP1LC3A-positive membranes to promote autophagy. When stimulated by growth factors, CCDC88A promotes the dissociation of GPSM1::GNAI3 complex to initiate anti-autophagy signalling pathways.
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InnateDB Annotation from Orthologs | |||||||||||||||||||
Summary |
[Mus musculus] Gpsm1, an inhibitor of Gnai3, plays a key role in regulating autophagy; the dynamic interplay between Gnai3, Gpsm1, and Ccdc88a determines whether autophagy is promoted or inhibited. During starving conditions, Gpsm1 binds to Gnai3 in Map1lc3a-positive membranes to promote autophagy. When stimulated by growth factors, Ccdc88a promotes the dissociation of Gpsm1::Gnai3 complex to initiate anti-autophagy signaling pathways.
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Entrez Gene | |||||||||||||||||||
Summary |
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 9:136327476-136359605 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q34.3 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.239370 Hs.595811 | ||||||||||||||||||
RefSeq | NM_001145638 NM_001145639 NM_001200003 NM_015597 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS48055 CCDS48056 CCDS6996 | ||||||||||||||||||
HPRD | 17075 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||