Homo sapiens Gene: CARD9
Summary
InnateDB Gene IDBG-92266.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD9
Gene Name caspase recruitment domain family, member 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187796
Encoded Proteins
caspase recruitment domain family, member 9
caspase recruitment domain family, member 9
caspase recruitment domain family, member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CARD9 signalling mediates mammalian innate immune responses against selected fungi, bacteria, and viruses and can prime and shape adaptive immunity. CARD9 plays an essential role in downstream signalling of the antifungal pattern-recognition receptor CLEC7A (Dectin-1).
CARD9 is critical for full activation of innate immunity by converging signals downstream of multiple pattern recognition receptors (PRRs) and plays a pivotal role in autonomous innate host defence against tuberculosis.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Card9 is critical for full activation of innate immunity by converging signals downstream of multiple pattern recognition receptors (PRRs) and plays a pivotal role in autonomous innate host defense against tuberculosis.
[Mus musculus] Card9 is largely dispensable for the innate immune response to oropharyngeal candidiasis whereas it is vital for the adaptive Th17 response.
[Mus musculus] Card9-mediated activation of the innate immune system exacerbates influenza pneumonia. Card9 deficiency improves mortality with reduced inflammatory cytokine/chemokines.
Entrez Gene
Summary The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:136361903-136373681
Strand Reverse strand
Band q34.3
Transcripts
ENST00000371732 ENSP00000360797
ENST00000371734 ENSP00000360799
ENST00000481053
ENST00000489932 ENSP00000451368
ENST00000460290
ENST00000485975
ENST00000556340
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0050700 CARD domain binding
Biological Process
GO:0009620 response to fungus
GO:0032494 response to peptidoglycan
GO:0032495 response to muramyl dipeptide
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042493 response to drug
GO:0042534 regulation of tumor necrosis factor biosynthetic process
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0045076 regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045089 positive regulation of innate immune response
GO:0045408 regulation of interleukin-6 biosynthetic process
GO:0046330 positive regulation of JNK cascade
GO:0050830 defense response to Gram-positive bacterium
GO:0051607 defense response to virus
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
NOD1/2 Signaling Pathway pathway
Immune System pathway
KEGG
NOD-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.694071
RefSeq NM_052813 NM_052814
HUGO
OMIM
CCDS CCDS48057 CCDS6997
HPRD 06236
IMGT
EMBL
GenPept
RNA Seq Atlas