Version 5.4
Homo sapiens Gene: MTO1
Summary
InnateDB Gene IDBG-92375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTO1
Gene Name mitochondrial translation optimization 1 homolog (S. cerevisiae)
Synonyms COXPD10
Species Homo sapiens
Ensembl Gene ENSG00000135297
Encoded Proteins
IDBP-92379
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-92383
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-383263
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-383269
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-383270
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-383271
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-474680
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-481534
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-473578
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-481191
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-482814
mitochondrial translation optimization 1 homolog (S. cerevisiae)
IDBP-474658
mitochondrial translation optimization 1 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:73461578-73509236
Strand Forward strand
Band q13
Transcripts
ENST00000370308
ENST00000370305 ENSP00000359328
ENST00000370300 ENSP00000359323
ENST00000415954 ENSP00000402038
ENST00000415228 ENSP00000416397
ENST00000442897 ENSP00000396529
ENST00000445187 ENSP00000407580
ENST00000498286 ENSP00000419561
ENST00000521032 ENSP00000428302
ENST00000522205 ENSP00000428903
ENST00000462039
ENST00000518210
ENST00000485082
ENST00000466977
ENST00000520366
ENST00000487960
ENST00000524046 ENSP00000430660
ENST00000521156 ENSP00000428863
ENST00000523763 ENSP00000429595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0044822 poly(A) RNA binding
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0008033 tRNA processing
GO:0055114 oxidation-reduction process
GO:0070899 mitochondrial tRNA wobble uridine modification
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032342
View Gene Order
ENSBTAG00000016839
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.347614
RefSeq NM_001123226 NM_012123 NM_133645 XM_006715444 XM_006715445 XM_006715446 XM_006715447 XM_006715448 XM_006715449
HUGO
OMIM
CCDS CCDS34485 CCDS47452 CCDS4979
HPRD 17611
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca