Homo sapiens Gene: BRCC3
Summary
InnateDB Gene IDBG-92384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRCC3
Gene Name BRCA1/BRCA2-containing complex, subunit 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185515
Encoded Proteins
BRCA1/BRCA2-containing complex, subunit 3
BRCA1/BRCA2-containing complex, subunit 3
BRCA1/BRCA2-containing complex, subunit 3
BRCA1/BRCA2-containing complex, subunit 3
BRCA1/BRCA2-containing complex, subunit 3
BRCA1/BRCA2-containing complex, subunit 3
BRCA1/BRCA2-containing complex, subunit 3
BRCA1/BRCA2-containing complex, subunit 3
BRCA1/BRCA2-containing complex, subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:155071420-155123074
Strand Forward strand
Band q28
Transcripts
ENST00000330045 ENSP00000328641
ENST00000369462 ENSP00000358474
ENST00000340647 ENSP00000344103
ENST00000369459 ENSP00000358471
ENST00000399042 ENSP00000381998
ENST00000399026 ENSP00000381988
ENST00000411985 ENSP00000413170
ENST00000453705 ENSP00000415152
ENST00000620502 ENSP00000482836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 66 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0030234 enzyme regulator activity
GO:0031593 polyubiquitin binding
GO:0046872 metal ion binding
Biological Process
GO:0006302 double-strand break repair
GO:0006508 proteolysis
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0031572 G2 DNA damage checkpoint
GO:0045739 positive regulation of DNA repair
GO:0050790 regulation of catalytic activity
GO:0070536 protein K63-linked deubiquitination
GO:0070537 histone H2A K63-linked deubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000152 nuclear ubiquitin ligase complex
GO:0005634 nucleus
GO:0070531 BRCA1-A complex
GO:0070552 BRISC complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P46736
TrEMBL
UniProt Splice Variant
Entrez Gene 79184
UniGene Hs.558537 Hs.669813 Hs.735783
RefSeq XM_005274749 XM_006724846 NM_001018055 NM_001242640 NM_024332 XM_005274751
HUGO HGNC:24185
OMIM 300617
CCDS CCDS56610 CCDS56611 CCDS56612
HPRD 06465
IMGT
EMBL AK298886 AK299194 AK313544 AY438030 BC002999 BC006540 BX293995 BX470111 S68015 X64643
GenPept AAB29005 AAH02999 AAH06540 AAR30498 BAG36320 BAG60999 BAG61237 CAA45917 CAH70537 CAH70538 CAI41654 CAI41655 CAO03573 CAO03574 CAO03575 CAO03576 CAO03601 CAO03602
RNA Seq Atlas 79184