Homo sapiens Gene: CHST15
Summary
InnateDB Gene IDBG-92594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHST15
Gene Name carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182022
Encoded Proteins
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:124007666-124093607
Strand Reverse strand
Band q26.13
Transcripts
ENST00000346248 ENSP00000333947
ENST00000435907 ENSP00000402394
ENST00000476765
ENST00000462406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding
GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0019319 hexose biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
GO:0030204 chondroitin sulfate metabolic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
BCR pathway
REACTOME
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Chondroitin sulfate biosynthesis pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective SLC26A2 causes chondrodysplasias pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
Glycosaminoglycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q7LFX5
TrEMBL
UniProt Splice Variant
Entrez Gene 51363
UniGene Hs.598695 Hs.614304 Hs.711426 Hs.731394
RefSeq NM_001270764 XM_005269891 XM_006717891 NM_015892
HUGO HGNC:18137
OMIM 608277
CCDS CCDS7638
HPRD 12203
IMGT
EMBL AB011170 AB025341 AB062423 AF026477 AL683842 BC027908 BC050540 BC075813 CR749804
GenPept AAC71691 AAH27908 AAH50540 AAH75813 BAA25524 BAA83686 BAB72145 CAH18664 CAI14442
RNA Seq Atlas 51363