Homo sapiens Gene: CTBP2
Summary
InnateDB Gene IDBG-92761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTBP2
Gene Name C-terminal binding protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000175029
Encoded Proteins
C-terminal binding protein 2
C-terminal binding protein 2
C-terminal binding protein 2
C-terminal binding protein 2
C-terminal binding protein 2
C-terminal binding protein 2
C-terminal binding protein 2
C-terminal binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. [provided by RefSeq, Jul 2008]
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3\' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:124984317-125161170
Strand Reverse strand
Band q26.13
Transcripts
ENST00000337195 ENSP00000338615
ENST00000309035 ENSP00000311825
ENST00000334808 ENSP00000357816
ENST00000395705 ENSP00000481909
ENST00000411419 ENSP00000410474
ENST00000486955
ENST00000460976
ENST00000493552
ENST00000494626 ENSP00000436285
ENST00000476817
ENST00000467395
ENST00000531469 ENSP00000434630
ENST00000530884 ENSP00000434424
ENST00000530930
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 98 [view]
Protein-Protein 98 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0008152 metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0019079 viral genome replication
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050872 white fat cell differentiation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
GO:0030054 cell junction
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Wnt pathway
REACTOME
truncated APC mutants destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of beta-catenin by the destruction complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
repression of WNT target genes pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
TCF7L2 mutants don't bind CTBP pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Notch signaling pathway pathway
Pathways in cancer pathway
Chronic myeloid leukemia pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P56545
TrEMBL
UniProt Splice Variant
Entrez Gene 1488
UniGene Hs.501345 Hs.664480 Hs.739999
RefSeq NM_001083914 NM_001329 NM_001290214 NM_001290215 NM_022802 XM_005269572 XM_005269571 XM_005269565 XM_005269561
HUGO HGNC:2495
OMIM 602619
CCDS CCDS7643 CCDS7644
HPRD 04016
IMGT
EMBL AF016507 AF222711 AK290390 AL596261 AL731571 AL833398 BC002486 BC047018 BC052276 BC072020 BT007012 CH471066
GenPept AAC39603 AAG45951 AAH02486 AAH47018 AAH52276 AAH72020 AAP35658 BAF83079 CAH10590 CAH72472 CAI16100 CAI16102 EAW49247 EAW49249 EAW49250
RNA Seq Atlas 1488