InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTBP2

Summary

InnateDB Gene

IDBG-92761.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTBP2

Gene Name

C-terminal binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000175029

Encoded Proteins

IDBP-92763

C-terminal binding protein 2

IDBP-92765

C-terminal binding protein 2

IDBP-92767

C-terminal binding protein 2

IDBP-813142

C-terminal binding protein 2

IDBP-386713

C-terminal binding protein 2

IDBP-592850

C-terminal binding protein 2

IDBP-592915

C-terminal binding protein 2

IDBP-595225

C-terminal binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. [provided by RefSeq, Jul 2008]
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3\' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:124984317-125161170

Strand

Reverse strand

Band

q26.13

Transcripts

ENST00000337195	ENSP00000338615
ENST00000309035	ENSP00000311825
ENST00000334808	ENSP00000357816
ENST00000395705	ENSP00000481909
ENST00000411419	ENSP00000410474
ENST00000486955
ENST00000460976
ENST00000493552
ENST00000494626	ENSP00000436285
ENST00000476817
ENST00000467395
ENST00000531469	ENSP00000434630
ENST00000530884	ENSP00000434424
ENST00000530930

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	98 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0019079	viral genome replication
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050872	white fat cell differentiation
GO:0055114	oxidation-reduction process