InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLA2G2A

Summary

InnateDB Gene

IDBG-92794.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G2A

Gene Name

phospholipase A2, group IIA (platelets, synovial fluid)

Synonyms

MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2

Species

Homo sapiens

Ensembl Gene

ENSG00000188257

Encoded Proteins

IDBP-92796

phospholipase A2, group IIA (platelets, synovial fluid)

IDBP-228059

phospholipase A2, group IIA (platelets, synovial fluid)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26644377

IL22 induced at an early stage of L. monocytogenes infection enhances innate immunity against L. monocytogenes in the liver by stimulating hepatocytes to produce an antimicrobial molecule, PLA2G2A

Entrez Gene

Summary

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5\' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:19975431-19980416

Strand

Reverse strand

Band

p36.13

Transcripts

ENST00000375111	ENSP00000364252
ENST00000400520	ENSP00000383364
ENST00000469162
ENST00000496748
ENST00000491964
ENST00000482011
ENST00000461140

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding
GO:0005543	phospholipid binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0008285	negative regulation of cell proliferation
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0016042	lipid catabolic process
GO:0034374	low-density lipoprotein particle remodeling
GO:0035019	somatic stem cell maintenance
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0042127	regulation of cell proliferation
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046473	phosphatidic acid metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050678	regulation of epithelial cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0030141	secretory granule