Version 5.4
Homo sapiens Gene: MMP21
Summary
InnateDB Gene IDBG-92837.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMP21
Gene Name matrix metallopeptidase 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154485
Encoded Proteins
IDBP-92839
matrix metallopeptidase 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:125766453-125775821
Strand Reverse strand
Band q26.2
Transcripts
ENST00000368808 ENSP00000357798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000030981
View Gene Order
Cross-References
SwissProt Q8N119
TrEMBL
UniProt Splice Variant
Entrez Gene 118856
UniGene Hs.314141
RefSeq NM_147191
HUGO HGNC:14357
OMIM 608416
CCDS CCDS7647
HPRD
IMGT
EMBL AF331526 AF520613 AL158835 AL360176 AY121358 AY885252
GenPept AAM75352 AAM78033 AAM92903 AAW62254 CAH73211 CAI12086
RNA Seq Atlas 118856

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca