Version 5.4
Homo sapiens Gene: MUL1
Summary
InnateDB Gene IDBG-92888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUL1
Gene Name mitochondrial E3 ubiquitin protein ligase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000090432
Encoded Proteins
IDBP-92890
mitochondrial E3 ubiquitin protein ligase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23399697
MUL1 limits inflammation by regulating the RIG-I anti-viral response.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:20499448-20508161
Strand Reverse strand
Band p36.12
Transcripts
ENST00000264198 ENSP00000264198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019789 SUMO ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
Biological Process
GO:0000266 mitochondrial fission
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007005 mitochondrion organization
GO:0007257 activation of JUN kinase activity
GO:0010637 negative regulation of mitochondrial fusion
GO:0016567 protein ubiquitination
GO:0016925 protein sumoylation
GO:0030308 negative regulation of cell growth
GO:0033235 positive regulation of protein sumoylation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045824 negative regulation of innate immune response
GO:0050689 negative regulation of defense response to virus by host
GO:0050821 protein stabilization
GO:0051646 mitochondrion localization
GO:0051898 negative regulation of protein kinase B signaling
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:0090141 positive regulation of mitochondrial fission
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0016020 membrane
GO:0031307 integral component of mitochondrial outer membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041241
View Gene Order
ENSBTAG00000020850
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.10101 Hs.702847
RefSeq NM_024544
HUGO
OMIM
CCDS CCDS208
HPRD 07799
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca