InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF4G3

Summary

InnateDB Gene

IDBG-93019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4G3

Gene Name

eukaryotic translation initiation factor 4 gamma, 3

Synonyms

eIF-4G 3; eIF4G 3; eIF4GII

Species

Homo sapiens

Ensembl Gene

ENSG00000075151

Encoded Proteins

IDBP-93023

eukaryotic translation initiation factor 4 gamma, 3

IDBP-93025

eukaryotic translation initiation factor 4 gamma, 3

IDBP-93029

eukaryotic translation initiation factor 4 gamma, 3

IDBP-228253

eukaryotic translation initiation factor 4 gamma, 3

IDBP-374010

eukaryotic translation initiation factor 4 gamma, 3

IDBP-374014

eukaryotic translation initiation factor 4 gamma, 3

IDBP-810504

eukaryotic translation initiation factor 4 gamma, 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:20806292-21176888

Strand

Reverse strand

Band

p36.12

Transcripts

ENST00000264211	ENSP00000264211
ENST00000374935	ENSP00000364071
ENST00000374933
ENST00000356916	ENSP00000349386
ENST00000400422	ENSP00000383274
ENST00000435383
ENST00000438975	ENSP00000395381
ENST00000411888	ENSP00000396083
ENST00000496705
ENST00000485722
ENST00000476088
ENST00000463775
ENST00000602326	ENSP00000473510

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000339	RNA cap binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0007283	spermatogenesis
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0045727	positive regulation of translation
GO:0060903	positive regulation of meiosis I

Cellular Component

GO:0005829	cytosol
GO:0016281	eukaryotic translation initiation factor 4F complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028760

View Gene Order

ENSBTAG00000040215

Not yet available

Pathways

NETPATH

REACTOME

REACT_115831

ISG15 antiviral mechanism pathway

REACT_115676

Antiviral mechanism by IFN-stimulated genes pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

hsa05416

Viral myocarditis pathway

hsa03013

RNA transport pathway

INOH

INOH website

Insulin receptor signaling pathway

PID NCI

Cross-References

SwissProt

O43432

TrEMBL

B1AN91

UniProt Splice Variant

Entrez Gene

8672

UniGene

Hs.467084 Hs.597213

RefSeq

NM_001198801 NM_001198802 NM_001198803 NM_003760

HUGO

HGNC:3298

OMIM

603929

CCDS

CCDS214 CCDS55580 CCDS59192 CCDS72723

HPRD

06802

IMGT

EMBL

AF012072 AL031005 AL358392 AL606477 AL627311 AL672037 BC030578 BC094683 BC136643 CH471134 Z34918

GenPept

AAC02903 AAH30578 AAH94683 AAI36644 CAA84397 CAI12155 CAI12534 CAI14553 EAW94956

RNA Seq Atlas

8672