Homo sapiens Gene: XRCC6
Summary
InnateDB Gene IDBG-9323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XRCC6
Gene Name X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms CTC75; CTCBF; G22P1; KU70; ML8; TLAA;
Species Homo sapiens
Ensembl Gene ENSG00000196419
Encoded Proteins
X-ray repair complementing defective repair in Chinese hamster cells 6
X-ray repair complementing defective repair in Chinese hamster cells 6
X-ray repair complementing defective repair in Chinese hamster cells 6
X-ray repair complementing defective repair in Chinese hamster cells 6
X-ray repair complementing defective repair in Chinese hamster cells 6
X-ray repair complementing defective repair in Chinese hamster cells 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Vaccinia virus protein C16 influences the immune response by binding to the XRCC6/XRCC5 (Ku70/80) complex thus blocking PRKDC-dependent DNA sensing in fibroblasts
Entrez Gene
Summary The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:41621119-41664048
Strand Forward strand
Band q13.2
Transcripts
ENST00000359308 ENSP00000352257
ENST00000360079 ENSP00000353192
ENST00000402580 ENSP00000384941
ENST00000405878 ENSP00000384257
ENST00000405506 ENSP00000384082
ENST00000428575 ENSP00000403679
ENST00000464116
ENST00000478914
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 347 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 347 [view]
Protein-Protein 341 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003691 double-stranded telomeric DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0042162 telomeric DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0044822 poly(A) RNA binding
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0000723 telomere maintenance
GO:0006266 DNA ligation
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0007420 brain development
GO:0010212 response to ionizing radiation
GO:0016032 viral process
GO:0032481 positive regulation of type I interferon production
GO:0032508 DNA duplex unwinding
GO:0033151 V(D)J recombination
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050769 positive regulation of neurogenesis
GO:0071475 cellular hyperosmotic salinity response
GO:0071481 cellular response to X-ray
GO:0075713 establishment of integrated proviral latency
Cellular Component
GO:0000783 nuclear telomere cap complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0043234 protein complex
GO:0043564 Ku70:Ku80 complex
GO:0070419 nonhomologous end joining complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
STING mediated induction of host immune responses pathway
IRF3-mediated induction of type I IFN pathway
Nonhomologous End-joining (NHEJ) pathway
Integration of provirus pathway
2-LTR circle formation pathway
Innate Immune System pathway
Double-Strand Break Repair pathway
Early Phase of HIV Life Cycle pathway
Immune System pathway
HIV Life Cycle pathway
Processing of DNA ends prior to end rejoining pathway
HIV Infection pathway
Cytosolic sensors of pathogen-associated DNA pathway
Disease pathway
DNA Repair pathway
KEGG
Non-homologous end-joining pathway
INOH
PID BIOCARTA
Telomeres telomerase cellular aging and immortality [Biocarta view]
PID NCI
Coregulation of Androgen receptor activity
Signaling events mediated by HDAC Class III
BARD1 signaling events
DNA-PK pathway in nonhomologous end joining
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.292493 Hs.500561 Hs.567992 Hs.625078 Hs.681716 Hs.730702
RefSeq NM_001288976 NM_001288977 NM_001288978 NM_001469
HUGO
OMIM
CCDS CCDS14021 CCDS74870 CCDS74871
HPRD 01071
IMGT
EMBL
GenPept
RNA Seq Atlas