Version 5.4
Homo sapiens Gene: TUBB4B
Summary
InnateDB Gene IDBG-93282.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUBB4B
Gene Name tubulin, beta 4B class IVb
Synonyms Beta2; TUBB2; TUBB2C
Species Homo sapiens
Ensembl Gene ENSG00000188229
Encoded Proteins
IDBP-93284
tubulin, beta 4B class IVb
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137241213-137243707
Strand Forward strand
Band q34.3
Transcripts
ENST00000340384 ENSP00000341289
ENST00000604929
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 121 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 121 [view]
Protein-Protein 121 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0042288 MHC class I protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006184 GTP catabolic process
GO:0006457 protein folding
GO:0006928 cellular component movement
GO:0007017 microtubule-based process
GO:0042267 natural killer cell mediated cytotoxicity
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
GO:0051225 spindle assembly
GO:0051258 protein polymerization
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036752
View Gene Order
ENSBTAG00000025274
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15510
Recruitment of NuMA to mitotic centrosomes pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_16967
Post-chaperonin tubulin folding pathway pathway
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16956
Formation of tubulin folding intermediates by CCT/TriC pathway
REACT_11039
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
REACT_11050
Transport of connexons to the plasma membrane pathway
REACT_9509
Gap junction assembly pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_16952
Protein folding pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_9411
Gap junction trafficking pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_115566
Cell Cycle pathway
REACT_267716
Orphan transporters pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04540
Gap junction pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.594600 Hs.735337
RefSeq NM_006088
HUGO
OMIM
CCDS CCDS7039
HPRD 04043
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca