Homo sapiens Gene: ECHS1
Summary
InnateDB Gene IDBG-93744.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECHS1
Gene Name enoyl CoA hydratase, short chain, 1, mitochondrial
Synonyms SCEH;
Species Homo sapiens
Ensembl Gene ENSG00000127884
Encoded Proteins
enoyl CoA hydratase, short chain, 1, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:133362480-133373689
Strand Reverse strand
Band q26.3
Transcripts
ENST00000368547 ENSP00000357535
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004300 enoyl-CoA hydratase activity
GO:0005515 protein binding
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
Metabolism pathway
KEGG
Fatty acid elongation pathway
Fatty acid degradation pathway
Valine, leucine and isoleucine degradation pathway
Lysine degradation pathway
Tryptophan metabolism pathway
beta-Alanine metabolism pathway
Propanoate metabolism pathway
Butanoate metabolism pathway
INOH
Lysine degradation pathway
Tryptophan degradation pathway
Propanoate metabolism pathway
Butanoate metabolism pathway
Valine Leucine Isoleucine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P30084
TrEMBL
UniProt Splice Variant
Entrez Gene 1892
UniGene Hs.76394
RefSeq NM_004092
HUGO HGNC:3151
OMIM 602292
CCDS CCDS7681
HPRD
IMGT
EMBL AL360181 BC008906 BT007123 D13900 X98126 X98127 X98128 X98129
GenPept AAH08906 AAP35787 BAA03001 CAA66808 CAH70286
RNA Seq Atlas 1892