InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CNR2

Summary

InnateDB Gene

IDBG-94061.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNR2

Gene Name

cannabinoid receptor 2 (macrophage)

Synonyms

CB-2; CB2; CX5

Species

Homo sapiens

Ensembl Gene

ENSG00000188822

Encoded Proteins

IDBP-94063

cannabinoid receptor 2 (macrophage)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:23870526-23913362

Strand

Reverse strand

Band

p36.11

Transcripts

ENST00000374472

ENSP00000363596

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004949	cannabinoid receptor activity

Biological Process

GO:0001975	response to amphetamine
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0019233	sensory perception of pain
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0032496	response to lipopolysaccharide
GO:0033004	negative regulation of mast cell activation
GO:0045759	negative regulation of action potential
GO:0050728	negative regulation of inflammatory response
GO:0051001	negative regulation of nitric-oxide synthase activity

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043204	perikaryon

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000062585

View Gene Order

ENSBTAG00000019371

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P34972

TrEMBL

A0A024RAH7

UniProt Splice Variant

Entrez Gene

1269

UniGene

Hs.73037

RefSeq

NM_001841 XM_005245736 XM_005245737 XM_005245738

HUGO

HGNC:2160

OMIM

605051

CCDS

CCDS245

HPRD

IMGT

EMBL

AJ430063 AJ430064 AL590609 AM156854 AM156855 AM156856 AY242132 BC069722 BC074767 BC095545 CH471134 EU517121 X74328

GenPept

AAH69722 AAH74767 AAH95545 AAO92299 ACD31539 CAA52376 CAD22548 CAD22549 CAI14799 CAJ42137 CAJ42138 CAJ42139 EAW95099 EAW95100

RNA Seq Atlas

1269