Homo sapiens Gene: CNR2
Summary
InnateDB Gene IDBG-94061.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNR2
Gene Name cannabinoid receptor 2 (macrophage)
Synonyms CB-2; CB2; CX5;
Species Homo sapiens
Ensembl Gene ENSG00000188822
Encoded Proteins
cannabinoid receptor 2 (macrophage)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:23870526-23913362
Strand Reverse strand
Band p36.11
Transcripts
ENST00000374472 ENSP00000363596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004949 cannabinoid receptor activity
Biological Process
GO:0001975 response to amphetamine
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0019233 sensory perception of pain
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0032496 response to lipopolysaccharide
GO:0033004 negative regulation of mast cell activation
GO:0045759 negative regulation of action potential
GO:0050728 negative regulation of inflammatory response
GO:0051001 negative regulation of nitric-oxide synthase activity
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043204 perikaryon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
Metabolism of anandamide an endogenous cannabinoid [Biocarta view]
PID NCI
Cross-References
SwissProt P34972
TrEMBL A0A024RAH7
UniProt Splice Variant
Entrez Gene 1269
UniGene Hs.73037
RefSeq NM_001841 XM_005245736 XM_005245737 XM_005245738
HUGO HGNC:2160
OMIM 605051
CCDS CCDS245
HPRD 05444
IMGT
EMBL AJ430063 AJ430064 AL590609 AM156854 AM156855 AM156856 AY242132 BC069722 BC074767 BC095545 CH471134 EU517121 X74328
GenPept AAH69722 AAH74767 AAH95545 AAO92299 ACD31539 CAA52376 CAD22548 CAD22549 CAI14799 CAJ42137 CAJ42138 CAJ42139 EAW95099 EAW95100
RNA Seq Atlas 1269