Homo sapiens Gene: TRIM63
Summary
InnateDB Gene IDBG-94466.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM63
Gene Name tripartite motif containing 63, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158022
Encoded Proteins
tripartite motif containing 63
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TRIM63 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:26051304-26068436
Strand Reverse strand
Band p36.11
Transcripts
ENST00000374272 ENSP00000363390
ENST00000483052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 128 [view]
Protein-Protein 128 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031432 titin binding
GO:0046872 metal ion binding
Biological Process
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0010468 regulation of gene expression
GO:0014732 skeletal muscle atrophy
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051384 response to glucocorticoid
GO:0070555 response to interleukin-1
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0030018 Z disc
GO:0031430 M band
GO:0043292 contractile fiber
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q969Q1
TrEMBL
UniProt Splice Variant
Entrez Gene 84676
UniGene Hs.279709
RefSeq NM_032588
HUGO HGNC:16007
OMIM 606131
CCDS CCDS273
HPRD 05843
IMGT
EMBL AF353673 AF361946 AJ276484 AJ291713 AK056942 AL391650 BC080529
GenPept AAH80529 AAK39519 AAK52497 BAB71318 CAC33173 CAC81706 CAI17133
RNA Seq Atlas 84676