Homo sapiens Gene: ATG5
Summary
InnateDB Gene IDBG-94856.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG5
Gene Name autophagy related 5
Synonyms APG5; APG5-LIKE; APG5L; ASP; hAPG5;
Species Homo sapiens
Ensembl Gene ENSG00000057663
Encoded Proteins
ATG5 autophagy related 5 homolog (S. cerevisiae)
ATG5 autophagy related 5 homolog (S. cerevisiae)
ATG5 autophagy related 5 homolog (S. cerevisiae)
ATG5 autophagy related 5 homolog (S. cerevisiae)
autophagy related 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ATG5 forms a conjugate with ATG12 to directly associate with DDX58 and MAVS and negatively regulate the antiviral IFN production pathway by mediating autophagy.
ATG12::ATG5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. ATG12::ATG5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Atg12::Atg5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. Atg12::Atg5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.
[Mus musculus] Atg5 knockout mice develop systemic and hepatic inflammation with high-fat diet and low-dose lipolysaccharide treatment.
[Mus musculus] Atg5 plays a unique role in protection against M. tuberculosis by preventing polymorphic mononuclear cell (PMN)-mediated immunopathology. Loss of Atg5 in PMNs can cause susceptibility to M. tuberculosis.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:106184476-106325820
Strand Reverse strand
Band q21
Transcripts
ENST00000369076 ENSP00000358072
ENST00000369070 ENSP00000358066
ENST00000343245 ENSP00000343313
ENST00000360666 ENSP00000353884
ENST00000475645
ENST00000476518
ENST00000613993 ENSP00000483135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 60 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0001974 blood vessel remodeling
GO:0002739 regulation of cytokine secretion involved in immune response
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0009620 response to fungus
GO:0031397 negative regulation of protein ubiquitination
GO:0032480 negative regulation of type I interferon production
GO:0039689 negative stranded viral RNA replication
GO:0042311 vasodilation
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0045087 innate immune response (InnateDB)
GO:0048840 otolith development
GO:0055015 ventricular cardiac muscle cell development
GO:0060047 heart contraction
GO:1902017 regulation of cilium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005930 axoneme
GO:0016020 membrane
GO:0034045 pre-autophagosomal structure membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Innate Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
KEGG
Regulation of autophagy pathway
RIG-I-like receptor signaling pathway pathway
Shigellosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.486063 Hs.603246
RefSeq NM_001286106 NM_001286107 NM_001286108 NM_001286111 NM_004849
HUGO
OMIM
CCDS CCDS5055 CCDS69159 CCDS75498
HPRD 16051
IMGT
EMBL
GenPept
RNA Seq Atlas