Homo sapiens Gene: PPP1R8
Summary
InnateDB Gene IDBG-95029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R8
Gene Name protein phosphatase 1, regulatory subunit 8
Synonyms ARD-1; ARD1; NIPP-1; NIPP1; PRO2047;
Species Homo sapiens
Ensembl Gene ENSG00000117751
Encoded Proteins
protein phosphatase 1, regulatory subunit 8
protein phosphatase 1, regulatory subunit 8
protein phosphatase 1, regulatory subunit 8
protein phosphatase 1, regulatory subunit 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:27830778-27851676
Strand Forward strand
Band p35.3
Transcripts
ENST00000311772 ENSP00000311677
ENST00000373931 ENSP00000363042
ENST00000236412 ENSP00000236412
ENST00000431586 ENSP00000410206
ENST00000486634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004865 protein serine/threonine phosphatase inhibitor activity
GO:0005515 protein binding
GO:0008599 protein phosphatase type 1 regulator activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0008283 cell proliferation
GO:0008380 RNA splicing
GO:0043086 negative regulation of catalytic activity
GO:0050790 regulation of catalytic activity
GO:0090501 RNA phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q12972
TrEMBL Q6ICT4
UniProt Splice Variant
Entrez Gene 5511
UniGene Hs.533474 Hs.618686
RefSeq NM_014110 NM_002713 NM_138558 XM_006710723
HUGO HGNC:9296
OMIM 602636
CCDS CCDS311 CCDS312 CCDS313
HPRD 04028
IMGT
EMBL AF061958 AF061959 AF064751 AF064752 AF064753 AF064754 AF064755 AF064756 AF064757 AF126488 AK292077 AK297771 AK313814 AL020997 AL109927 BC001597 BC013360 CH471059 CR450309 U14575
GenPept AAA64749 AAD22486 AAD24669 AAD24670 AAD31541 AAD31542 AAH01597 AAH13360 BAF84766 BAG36550 BAG60117 CAG29305 CAI20576 CAI20577 CAI20578 CAI21779 CAI21780 CAI21781 EAX07731 EAX07732 EAX07736
RNA Seq Atlas 5511