Homo sapiens Gene: RPA2
Summary
InnateDB Gene IDBG-95078.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPA2
Gene Name replication protein A2, 32kDa
Synonyms REPA2; RP-A p32; RP-A p34; RPA32;
Species Homo sapiens
Ensembl Gene ENSG00000117748
Encoded Proteins
replication protein A2, 32kDa
replication protein A2, 32kDa
replication protein A2, 32kDa
replication protein A2, 32kDa
replication protein A2, 32kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:27891524-27914746
Strand Reverse strand
Band p35.3
Transcripts
ENST00000373912 ENSP00000363021
ENST00000373909 ENSP00000363017
ENST00000313433 ENSP00000363015
ENST00000419958 ENSP00000413541
ENST00000444045 ENSP00000387649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 483 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 483 [view]
Protein-Protein 478 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000718 nucleotide-excision repair, DNA damage removal
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000730 DNA recombinase assembly
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006298 mismatch repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0032201 telomere maintenance via semi-conservative replication
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005662 DNA replication factor A complex
GO:0016605 PML body
GO:0035861 site of double-strand break
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
Cellular responses to stress pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Transcription-coupled NER (TC-NER) pathway
Synthesis of DNA pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Removal of the Flap Intermediate from the C-strand pathway
Regulation of HSF1-mediated heat shock response pathway
Homologous Recombination Repair pathway
Removal of the Flap Intermediate pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Formation of incision complex in GG-NER pathway
Chromosome Maintenance pathway
G2/M Checkpoints pathway
Processing of DNA double-strand break ends pathway
Dual incision reaction in GG-NER pathway
DNA Replication Pre-Initiation pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
G1/S Transition pathway
Double-Strand Break Repair pathway
Activation of the pre-replicative complex pathway
Cell Cycle pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Meiotic recombination pathway
Cellular response to heat stress pathway
Processive synthesis on the lagging strand pathway
M/G1 Transition pathway
Homologous DNA pairing and strand exchange pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Mismatch Repair pathway
Processive synthesis on the C-strand of the telomere pathway
Meiosis pathway
HSF1 activation pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Presynaptic phase of homologous DNA pairing and strand exchange pathway
Nucleotide Excision Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
DNA Repair pathway
Assembly of the RAD51-ssDNA nucleoprotein complex pathway
Cell Cycle Checkpoints pathway
KEGG
DNA replication pathway
Nucleotide excision repair pathway
Mismatch repair pathway
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Fanconi anemia pathway
ATR signaling pathway
Cross-References
SwissProt P15927
TrEMBL B4DL94 B4DQD9 B4DUL2 Q5TEJ0 Q5TEJ7
UniProt Splice Variant
Entrez Gene 6118
UniGene Hs.703070 Hs.79411
RefSeq NM_001286076 NM_001297558 NM_002946 XM_005245965
HUGO HGNC:10290
OMIM 179836
CCDS CCDS314 CCDS72740
HPRD
IMGT
EMBL AK296898 AK298759 AK300691 AL109927 BC001630 BC012157 BC021257 CR450348 DQ001128 J05249
GenPept AAA36560 AAH01630 AAH12157 AAH21257 AAX84514 BAG59456 BAG60901 BAG62374 CAG29344 CAI21775 CAI21777 CAI21778
RNA Seq Atlas 6118