Homo sapiens Gene: WASF1
Summary
InnateDB Gene IDBG-95204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WASF1
Gene Name WAS protein family, member 1
Synonyms SCAR1; WAVE; WAVE1;
Species Homo sapiens
Ensembl Gene ENSG00000112290
Encoded Proteins
WAS protein family, member 1
WAS protein family, member 1
WAS protein family, member 1
WAS protein family, member 1
WAS protein family, member 1
WAS protein family, member 1
WAS protein family, member 1
WAS protein family, member 1
WAS protein family, member 1
WAS protein family, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:110099819-110180004
Strand Reverse strand
Band q21
Transcripts
ENST00000359451 ENSP00000352425
ENST00000368938 ENSP00000357934
ENST00000265601 ENSP00000265601
ENST00000392589 ENSP00000376368
ENST00000392588 ENSP00000376367
ENST00000392587 ENSP00000376366
ENST00000392586 ENSP00000376365
ENST00000444391 ENSP00000407041
ENST00000419252 ENSP00000404142
ENST00000447287 ENSP00000402663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0006461 protein complex assembly
GO:0006928 cellular component movement
GO:0016601 Rac protein signal transduction
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0031209 SCAR complex
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Signaling by VEGF pathway
Innate Immune System pathway
Signal Transduction pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
Adherens junction pathway
Fc gamma R-mediated phagocytosis pathway
Regulation of actin cytoskeleton pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
INOH
PID BIOCARTA
How does salmonella hijack a cell [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
PID NCI
RAC1 signaling pathway
E2F transcription factor network
Cross-References
SwissProt
TrEMBL Q5SZK3 Q5SZK4
UniProt Splice Variant
Entrez Gene 8936
UniGene Hs.706833 Hs.75850
RefSeq NM_001024935 NM_001024936 NM_001024934 NM_003931 XM_005267207 XM_005267208 XM_005267205 XM_005267204 XM_006715595 XM_005267206
HUGO HGNC:12732
OMIM 605035
CCDS CCDS5080
HPRD 05434
IMGT
EMBL AL590009 AL590549 AL671518
GenPept
RNA Seq Atlas 8936