Version 5.4
Homo sapiens Gene: MAX
Summary
InnateDB Gene IDBG-9524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAX
Gene Name MYC associated factor X
Synonyms bHLHd4
Species Homo sapiens
Ensembl Gene ENSG00000125952
Encoded Proteins
IDBP-9526
MYC associated factor X
IDBP-9528
MYC associated factor X
IDBP-9530
MYC associated factor X
IDBP-9532
MYC associated factor X
IDBP-9534
MYC associated factor X
IDBP-241232
MYC associated factor X
IDBP-585413
MYC associated factor X
IDBP-594585
MYC associated factor X
IDBP-591090
MYC associated factor X
IDBP-588430
MYC associated factor X
IDBP-596833
MYC associated factor X
IDBP-585576
MYC associated factor X
IDBP-595148
MYC associated factor X
IDBP-586593
MYC associated factor X
IDBP-593800
MYC associated factor X
IDBP-810429
MYC associated factor X
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:65006174-65102695
Strand Reverse strand
Band q23.3
Transcripts
ENST00000341653 ENSP00000342482
ENST00000358664 ENSP00000351490
ENST00000284165 ENSP00000284165
ENST00000358402 ENSP00000351175
ENST00000246163 ENSP00000246163
ENST00000394606 ENSP00000378104
ENST00000555932 ENSP00000450763
ENST00000555419 ENSP00000452405
ENST00000553928 ENSP00000451907
ENST00000557277 ENSP00000450955
ENST00000556892 ENSP00000452206
ENST00000553951
ENST00000556979 ENSP00000452378
ENST00000555667 ENSP00000452286
ENST00000557746 ENSP00000452197
ENST00000556443 ENSP00000450818
ENST00000556702
ENST00000554709
ENST00000618858 ENSP00000480127
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 817 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 817 [view]
Protein-Protein 87 [view]
Protein-DNA 730 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0009267 cellular response to starvation
GO:0010243 response to organonitrogen compound
GO:0010629 negative regulation of gene expression
GO:0032868 response to insulin
GO:0048678 response to axon injury
GO:0051402 neuron apoptotic process
GO:0060041 retina development in camera-type eye
GO:0071375 cellular response to peptide hormone stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0030425 dendrite
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059436
View Gene Order
ENSBTAG00000017994
Not yet available
Pathways
NETPATH
REACTOME
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
myc_activpathway
Validated targets of C-MYC transcriptional activation
hdac_classi_pathway
Signaling events mediated by HDAC Class I
myc_pathway
C-MYC pathway
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.285354
RefSeq NM_002382 NM_145112 NM_145113 NM_145114 NM_197957
HUGO
OMIM
CCDS CCDS41965 CCDS9770 CCDS9771 CCDS9772 CCDS9774
HPRD 01113
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca