Homo sapiens Gene: MAX
Summary
InnateDB Gene IDBG-9524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAX
Gene Name MYC associated factor X
Synonyms bHLHd4;
Species Homo sapiens
Ensembl Gene ENSG00000125952
Encoded Proteins
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:65006174-65102695
Strand Reverse strand
Band q23.3
Transcripts
ENST00000341653 ENSP00000342482
ENST00000358664 ENSP00000351490
ENST00000284165 ENSP00000284165
ENST00000358402 ENSP00000351175
ENST00000246163 ENSP00000246163
ENST00000394606 ENSP00000378104
ENST00000555932 ENSP00000450763
ENST00000555419 ENSP00000452405
ENST00000553928 ENSP00000451907
ENST00000557277 ENSP00000450955
ENST00000556892 ENSP00000452206
ENST00000553951
ENST00000556979 ENSP00000452378
ENST00000555667 ENSP00000452286
ENST00000557746 ENSP00000452197
ENST00000556443 ENSP00000450818
ENST00000556702
ENST00000554709
ENST00000618858 ENSP00000480127
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 817 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 817 [view]
Protein-Protein 87 [view]
Protein-DNA 730 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0009267 cellular response to starvation
GO:0010243 response to organonitrogen compound
GO:0010629 negative regulation of gene expression
GO:0032868 response to insulin
GO:0048678 response to axon injury
GO:0051402 neuron apoptotic process
GO:0060041 retina development in camera-type eye
GO:0071375 cellular response to peptide hormone stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0030425 dendrite
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
Cyclin E associated events during G1/S transition pathway
Cell Cycle, Mitotic pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
KEGG
MAPK signaling pathway pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Overview of telomerase protein component gene htert transcriptional regulation [Biocarta view]
P38 mapk signaling pathway [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
PID NCI
Validated targets of C-MYC transcriptional repression
Validated targets of C-MYC transcriptional activation
Signaling events mediated by HDAC Class I
C-MYC pathway
Regulation of nuclear SMAD2/3 signaling
Regulation of Telomerase
Cross-References
SwissProt P61244
TrEMBL A0A024R682
UniProt Splice Variant
Entrez Gene 4149
UniGene Hs.285354
RefSeq NM_002382 NM_145112 NM_145113 NM_145114 NM_197957
HUGO HGNC:6913
OMIM 154950
CCDS CCDS41965 CCDS9770 CCDS9771 CCDS9772 CCDS9774
HPRD 01113
IMGT
EMBL AK290130 AK290929 AK292189 AK292630 AL139022 BC003525 BC004516 BC013669 BC027924 CH471061 M64240 X60287 X66867
GenPept AAA36200 AAA36201 AAH03525 AAH04516 AAH13669 AAH27924 BAF82819 BAF83618 BAF84878 BAF85319 CAA42827 CAA47337 CAA47338 CAA47339 EAW80899 EAW80901 EAW80903 EAW80904 EAW80906
RNA Seq Atlas 4149