InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ENPP1

Summary

InnateDB Gene

IDBG-96591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENPP1

Gene Name

ectonucleotide pyrophosphatase/phosphodiesterase 1

Synonyms

ARHR2; COLED; M6S1; NPP1; NPPS; PC-1; PCA1; PDNP1

Species

Homo sapiens

Ensembl Gene

ENSG00000197594

Encoded Proteins

IDBP-96597

ectonucleotide pyrophosphatase/phosphodiesterase 1

IDBP-473584

ectonucleotide pyrophosphatase/phosphodiesterase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5\' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with \'idiopathic\' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:131808016-131895155

Strand

Forward strand

Band

q23.2

Transcripts

ENST00000360971	ENSP00000354238
ENST00000486853
ENST00000513998	ENSP00000422424
ENST00000459624

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004528	phosphodiesterase I activity
GO:0004551	nucleotide diphosphatase activity
GO:0005044	scavenger receptor activity
GO:0005158	insulin receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0030247	polysaccharide binding
GO:0035529	NADH pyrophosphatase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0047429	nucleoside-triphosphate diphosphatase activity
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006200	ATP catabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006771	riboflavin metabolic process
GO:0006796	phosphate-containing compound metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0008152	metabolic process
GO:0009143	nucleoside triphosphate catabolic process
GO:0030279	negative regulation of ossification
GO:0030308	negative regulation of cell growth
GO:0030500	regulation of bone mineralization
GO:0030505	inorganic diphosphate transport
GO:0030643	cellular phosphate ion homeostasis
GO:0030730	sequestering of triglyceride
GO:0031214	biomineral tissue development
GO:0031953	negative regulation of protein autophosphorylation
GO:0032869	cellular response to insulin stimulus
GO:0044281	small molecule metabolic process
GO:0045599	negative regulation of fat cell differentiation
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0046325	negative regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0046849	bone remodeling
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane