Homo sapiens Gene: CYP2D6
Summary
InnateDB Gene IDBG-9690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP2D6
Gene Name cytochrome P450, family 2, subfamily D, polypeptide 6
Synonyms CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1;
Species Homo sapiens
Ensembl Gene ENSG00000100197
Encoded Proteins
cytochrome P450, family 2, subfamily D, polypeptide 6
cytochrome P450, family 2, subfamily D, polypeptide 6
cytochrome P450, family 2, subfamily D, polypeptide 6
cytochrome P450, family 2, subfamily D, polypeptide 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25%% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme\'s substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:42126499-42130906
Strand Reverse strand
Band q13.2
Transcripts
ENST00000359033 ENSP00000351927
ENST00000360124 ENSP00000353241
ENST00000360608 ENSP00000353820
ENST00000389970 ENSP00000374620
ENST00000488442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008144 drug binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0009804 coumarin metabolic process
GO:0009820 alkaloid metabolic process
GO:0009822 alkaloid catabolic process
GO:0016098 monoterpenoid metabolic process
GO:0017144 drug metabolic process
GO:0033076 isoquinoline alkaloid metabolic process
GO:0042737 drug catabolic process
GO:0044281 small molecule metabolic process
GO:0046483 heterocycle metabolic process
GO:0051100 negative regulation of binding
GO:0055114 oxidation-reduction process
GO:0070989 oxidative demethylation
GO:0090350 negative regulation of cellular organofluorine metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
CYP2E1 reactions pathway
Cytochrome P450 - arranged by substrate type pathway
Fatty acids pathway
Xenobiotics pathway
Metabolism pathway
Biological oxidations pathway
Miscellaneous substrates pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1565
UniGene Hs.648256
RefSeq NM_001025161 NM_000106 XM_006726320 XM_006726317 XM_006724157
HUGO HGNC:2625
OMIM 124030
CCDS CCDS33657 CCDS46721
HPRD 00487
IMGT
EMBL
GenPept
RNA Seq Atlas 101929829 1565