Homo sapiens Gene: BCLAF1
Summary
InnateDB Gene IDBG-96919.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCLAF1
Gene Name BCL2-associated transcription factor 1
Synonyms bK211L9.1; BTF;
Species Homo sapiens
Ensembl Gene ENSG00000029363
Encoded Proteins
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
BCL2-associated transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:136256863-136289851
Strand Reverse strand
Band q23.3
Transcripts
ENST00000353331 ENSP00000229446
ENST00000392348 ENSP00000376159
ENST00000476194
ENST00000531224 ENSP00000435210
ENST00000533422 ENSP00000437333
ENST00000527536 ENSP00000435441
ENST00000527613 ENSP00000436216
ENST00000530767 ENSP00000436501
ENST00000527759 ENSP00000434826
ENST00000534269 ENSP00000433822
ENST00000529522
ENST00000532384 ENSP00000433505
ENST00000530429 ENSP00000436142
ENST00000534762 ENSP00000437018
ENST00000529917
ENST00000526228
ENST00000534321
ENST00000534792
ENST00000532076
ENST00000529826 ENSP00000431734
ENST00000533621 ENSP00000436913
ENST00000528229
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 51 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043620 regulation of DNA-dependent transcription in response to stress
GO:0045892 negative regulation of transcription, DNA-templated
GO:2000144 positive regulation of DNA-dependent transcription, initiation
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9NYF8
TrEMBL B0AZU3
UniProt Splice Variant
Entrez Gene 9774
UniGene Hs.486542 Hs.601398 Hs.617546 Hs.627320 Hs.710172 Hs.718334
RefSeq NM_001301038 XM_005267236 NM_001077440 NM_014739 NM_001077441 XM_005267239
HUGO HGNC:16863
OMIM 612588
CCDS CCDS75525 CCDS47486 CCDS5177 CCDS47485
HPRD 16544
IMGT
EMBL AF249273 AK315884 AL121713 BC047687 BC047887 BC056894 BC063846 BC132780 BC144281 CH471051 D79986
GenPept AAF64304 AAH47687 AAH47887 AAH56894 AAH63846 AAI32781 AAI44282 BAA11481 BAF98775 CAB96722 EAW47950 EAW47951
RNA Seq Atlas 9774