Homo sapiens Gene: PPIH
Summary
InnateDB Gene IDBG-97224.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPIH
Gene Name peptidylprolyl isomerase H (cyclophilin H)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171960
Encoded Proteins
peptidylprolyl isomerase H (cyclophilin H)
peptidylprolyl isomerase H (cyclophilin H)
peptidylprolyl isomerase H (cyclophilin H)
peptidylprolyl isomerase H (cyclophilin H)
peptidylprolyl isomerase H (cyclophilin H)
peptidylprolyl isomerase H (cyclophilin H)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:42658425-42676758
Strand Forward strand
Band p34.2
Transcripts
ENST00000304979 ENSP00000306614
ENST00000372550 ENSP00000361630
ENST00000372549 ENSP00000361629
ENST00000440068 ENSP00000402836
ENST00000436387 ENSP00000405493
ENST00000461351 ENSP00000436091
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0016018 cyclosporin A binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0006461 protein complex assembly
GO:0045070 positive regulation of viral genome replication
Cellular Component
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9JQD4
UniProt Splice Variant
Entrez Gene 10465
UniGene Hs.256639
RefSeq NM_006347 XM_005270364 XM_006710293 XM_005270362
HUGO HGNC:14651
OMIM 606095
CCDS CCDS469
HPRD 12084
IMGT
EMBL AC098484
GenPept
RNA Seq Atlas 10465