Homo sapiens Gene: KIF2C
Summary
InnateDB Gene IDBG-97762.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF2C
Gene Name kinesin family member 2C
Synonyms CT139; KNSL6; MCAK;
Species Homo sapiens
Ensembl Gene ENSG00000142945
Encoded Proteins
kinesin family member 2C
kinesin family member 2C
kinesin family member 2C
kinesin family member 2C
kinesin family member 2C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. [provided by RefSeq, Jul 2008]
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:44739818-44767767
Strand Forward strand
Band p34.1
Transcripts
ENST00000372224 ENSP00000361298
ENST00000372217 ENSP00000361291
ENST00000452259 ENSP00000410346
ENST00000455186 ENSP00000395050
ENST00000423289 ENSP00000402172
ENST00000493027
ENST00000480574
ENST00000472235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 28 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0019237 centromeric DNA binding
GO:0051010 microtubule plus-end binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007018 microtubule-based movement
GO:0007019 microtubule depolymerization
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity
GO:0051983 regulation of chromosome segregation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0035371 microtubule plus-end
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Kinesins pathway
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
M Phase pathway
Mitotic Anaphase pathway
Factors involved in megakaryocyte development and platelet production pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Hemostasis pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Aurora B signaling
Cross-References
SwissProt
TrEMBL Q5JR89
UniProt Splice Variant
Entrez Gene 11004
UniGene Hs.720061 Hs.733568
RefSeq NM_006845 NM_001297657 NM_001297656 XM_005270394 XM_005270396
HUGO HGNC:6393
OMIM 604538
CCDS CCDS512 CCDS72774
HPRD 05172
IMGT
EMBL AL592166
GenPept
RNA Seq Atlas 11004