Version 5.4
Homo sapiens Gene: NTHL1
Summary
InnateDB Gene IDBG-9789.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTHL1
Gene Name nth endonuclease III-like 1 (E. coli)
Synonyms hNTH1; NTH1; OCTS3
Species Homo sapiens
Ensembl Gene ENSG00000065057
Encoded Proteins
IDBP-9791
nth endonuclease III-like 1 (E. coli)
IDBP-751759
IDBP-750682
IDBP-749764
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2039815-2047866
Strand Reverse strand
Band p13.3
Transcripts
ENST00000219066 ENSP00000219066
ENST00000568513 ENSP00000457818
ENST00000562951
ENST00000562120
ENST00000561841 ENSP00000456301
ENST00000567727
ENST00000566380 ENSP00000455267
ENST00000561862
ENST00000565406
ENST00000623977
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003824 catalytic activity
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0019104 DNA N-glycosylase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0045008 depyrimidination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041429
View Gene Order
ENSBTAG00000006272
Not yet available
Pathways
NETPATH
REACTOME
REACT_1064
Displacement of DNA glycosylase by APE1 pathway
REACT_1357
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_2156
Cleavage of the damaged pyrimidine pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_702
Recognition and association of DNA glycosylase with site containing an affected pyrimidine pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1405
Depyrimidination pathway
REACT_1104
Base Excision Repair pathway
REACT_804
Base-Excision Repair, AP Site Formation pathway
REACT_216
DNA Repair pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.66196
RefSeq NM_002528
HUGO
OMIM
CCDS CCDS10457
HPRD 04039
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca