Homo sapiens Gene: PRDX1
Summary
InnateDB Gene IDBG-97953.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDX1
Gene Name peroxiredoxin 1
Synonyms MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2;
Species Homo sapiens
Ensembl Gene ENSG00000117450
Encoded Proteins
peroxiredoxin 1
peroxiredoxin 1
peroxiredoxin 1
peroxiredoxin 1
peroxiredoxin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:45511036-45523047
Strand Reverse strand
Band p34.1
Transcripts
ENST00000262746 ENSP00000262746
ENST00000319248 ENSP00000361152
ENST00000372079 ENSP00000361150
ENST00000424390 ENSP00000389047
ENST00000447184 ENSP00000407034
ENST00000483583
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 108 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 108 [view]
Protein-Protein 108 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0008379 thioredoxin peroxidase activity
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0051920 peroxiredoxin activity
Biological Process
GO:0000302 response to reactive oxygen species
GO:0001501 skeletal system development
GO:0001895 retina homeostasis
GO:0006979 response to oxidative stress
GO:0008283 cell proliferation
GO:0019430 removal of superoxide radicals
GO:0032872 regulation of stress-activated MAPK cascade
GO:0034101 erythrocyte homeostasis
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042345 regulation of NF-kappaB import into nucleus
GO:0042744 hydrogen peroxide catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
Cellular responses to stress pathway
Detoxification of Reactive Oxygen Species pathway
KEGG
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
Cross-References
SwissProt Q06830
TrEMBL
UniProt Splice Variant
Entrez Gene 5052
UniGene Hs.681569
RefSeq NM_001202431 NM_002574 NM_181696 NM_181697
HUGO HGNC:9352
OMIM 176763
CCDS CCDS522
HPRD
IMGT
EMBL AB451262 AB451388 AL451136 BC007063 BC021683 BT019740 CH471059 CR407652 DQ297142 L19184 X67951
GenPept AAA50464 AAH07063 AAH21683 AAV38545 ABB84465 BAG70076 BAG70202 CAA48137 CAG28580 CAI13095 CAI13096 CAI13097 EAX06975 EAX06976 EAX06978 EAX06979 EAX06980 EAX06981 EAX06982
RNA Seq Atlas 5052