InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VIP

Summary

InnateDB Gene

IDBG-98129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VIP

Gene Name

vasoactive intestinal peptide

Synonyms

PHM27

Species

Homo sapiens

Ensembl Gene

ENSG00000146469

Encoded Proteins

IDBP-98131

vasoactive intestinal peptide

IDBP-98133

vasoactive intestinal peptide

IDBP-387948

vasoactive intestinal peptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:152750798-152759765

Strand

Forward strand

Band

q25.2

Transcripts

ENST00000367244	ENSP00000356213
ENST00000367243	ENSP00000356212
ENST00000431366	ENSP00000410356

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0005515	protein binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007589	body fluid secretion
GO:0007611	learning or memory
GO:0008284	positive regulation of cell proliferation
GO:0009966	regulation of signal transduction
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0032880	regulation of protein localization
GO:0043066	negative regulation of apoptotic process
GO:0043267	negative regulation of potassium ion transport
GO:0045732	positive regulation of protein catabolic process
GO:0045909	positive regulation of vasodilation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051930	regulation of sensory perception of pain
GO:0060406	positive regulation of penile erection

Cellular Component

GO:0005576	extracellular region
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019772

View Gene Order

ENSBTAG00000013400

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

INOH

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

P01282

TrEMBL

UniProt Splice Variant

Entrez Gene

7432

UniGene

Hs.53973 Hs.742000

RefSeq

NM_003381 NM_194435 XM_005267135 XM_006715562

HUGO

HGNC:12693

OMIM

192320

CCDS

CCDS5240 CCDS5241

HPRD

IMGT

EMBL

AL133356 BC009794 L00154 L00155 L00156 L00157 M11549 M11550 M11551 M11552 M11553 M14619 M14620 M14621 M14622 M14623 M31645 M32162 M33027 M36606 M36607 M36608 M36609 M36610 M36634 M54930

GenPept

AAA61284 AAA61285 AAA61286 AAA61287 AAA61288 AAA61289 AAA63268 AAA69515 AAH09794 CAI21764 CAI21765

RNA Seq Atlas

7432