Homo sapiens Gene: VIP
Summary
InnateDB Gene IDBG-98129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VIP
Gene Name vasoactive intestinal peptide
Synonyms PHM27;
Species Homo sapiens
Ensembl Gene ENSG00000146469
Encoded Proteins
vasoactive intestinal peptide
vasoactive intestinal peptide
vasoactive intestinal peptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:152750798-152759765
Strand Forward strand
Band q25.2
Transcripts
ENST00000367244 ENSP00000356213
ENST00000367243 ENSP00000356212
ENST00000431366 ENSP00000410356
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007589 body fluid secretion
GO:0007611 learning or memory
GO:0008284 positive regulation of cell proliferation
GO:0009966 regulation of signal transduction
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0032880 regulation of protein localization
GO:0043066 negative regulation of apoptotic process
GO:0043267 negative regulation of potassium ion transport
GO:0045732 positive regulation of protein catabolic process
GO:0045909 positive regulation of vasodilation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051930 regulation of sensory perception of pain
GO:0060406 positive regulation of penile erection
Cellular Component
GO:0005576 extracellular region
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 7432
UniGene Hs.53973 Hs.742000
RefSeq NM_003381 NM_194435 XM_006715562 XM_005267135
HUGO HGNC:12693
OMIM 192320
CCDS CCDS5240 CCDS5241
HPRD 15950
IMGT
EMBL
GenPept
RNA Seq Atlas 7432