InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TCP1

Summary

InnateDB Gene

IDBG-98570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCP1

Gene Name

t-complex 1

Synonyms

CCT-alpha; CCT1; CCTa; D6S230E; TCP-1-alpha

Species

Homo sapiens

Ensembl Gene

ENSG00000120438

Encoded Proteins

IDBP-98572

t-complex 1

IDBP-246202

t-complex 1

IDBP-388133

t-complex 1

IDBP-601902

t-complex 1

IDBP-597458

t-complex 1

IDBP-597540

t-complex 1

IDBP-602553

t-complex 1

IDBP-584714

t-complex 1

IDBP-596314

t-complex 1

IDBP-585758

t-complex 1

IDBP-585527

t-complex 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:159778498-159789749

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000321394	ENSP00000317334
ENST00000392168	ENSP00000376008
ENST00000420894	ENSP00000390159
ENST00000467544
ENST00000544255	ENSP00000439447
ENST00000546204
ENST00000539756	ENSP00000441345
ENST00000536807
ENST00000538530	ENSP00000440617
ENST00000543532
ENST00000538128	ENSP00000442185
ENST00000543517	ENSP00000444423
ENST00000539948	ENSP00000439671
ENST00000545764
ENST00000537390	ENSP00000437840
ENST00000536394	ENSP00000442856
ENST00000536607
ENST00000546023

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 143 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	143 [view]
Protein-Protein	139 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007021	tubulin complex assembly
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding

Cellular Component

GO:0000242	pericentriolar material
GO:0000792	heterochromatin
GO:0001669	acrosomal vesicle
GO:0002199	zona pellucida receptor complex
GO:0005720	nuclear heterochromatin
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome