Homo sapiens Gene: TCP1
Summary
InnateDB Gene IDBG-98570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCP1
Gene Name t-complex 1
Synonyms CCT-alpha; CCT1; CCTa; D6S230E; TCP-1-alpha;
Species Homo sapiens
Ensembl Gene ENSG00000120438
Encoded Proteins
t-complex 1
t-complex 1
t-complex 1
t-complex 1
t-complex 1
t-complex 1
t-complex 1
t-complex 1
t-complex 1
t-complex 1
t-complex 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:159778498-159789749
Strand Reverse strand
Band q25.3
Transcripts
ENST00000321394 ENSP00000317334
ENST00000392168 ENSP00000376008
ENST00000420894 ENSP00000390159
ENST00000467544
ENST00000544255 ENSP00000439447
ENST00000546204
ENST00000539756 ENSP00000441345
ENST00000536807
ENST00000538530 ENSP00000440617
ENST00000543532
ENST00000538128 ENSP00000442185
ENST00000543517 ENSP00000444423
ENST00000539948 ENSP00000439671
ENST00000545764
ENST00000537390 ENSP00000437840
ENST00000536394 ENSP00000442856
ENST00000536607
ENST00000546023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 143 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 143 [view]
Protein-Protein 139 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007021 tubulin complex assembly
GO:0007339 binding of sperm to zona pellucida
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0000242 pericentriolar material
GO:0000792 heterochromatin
GO:0001669 acrosomal vesicle
GO:0002199 zona pellucida receptor complex
GO:0005720 nuclear heterochromatin
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Formation of tubulin folding intermediates by CCT/TriC pathway
Protein folding pathway
Folding of actin by CCT/TriC pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.363137 Hs.743896
RefSeq NM_001008897 NM_030752
HUGO
OMIM
CCDS CCDS43522 CCDS5269
HPRD 01748
IMGT
EMBL
GenPept
RNA Seq Atlas