Homo sapiens Gene: ZFYVE9
Summary
InnateDB Gene IDBG-98606.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFYVE9
Gene Name zinc finger, FYVE domain containing 9
Synonyms MADHIP; NSP; PPP1R173; SARA; SMADIP;
Species Homo sapiens
Ensembl Gene ENSG00000157077
Encoded Proteins
zinc finger, FYVE domain containing 9
zinc finger, FYVE domain containing 9
zinc finger, FYVE domain containing 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:52142094-52346686
Strand Forward strand
Band p32.3
Transcripts
ENST00000287727 ENSP00000287727
ENST00000357206 ENSP00000349737
ENST00000361625
ENST00000371591 ENSP00000360647
ENST00000469134
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
Experimentally validated
Total 75 [view]
Protein-Protein 75 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006897 endocytosis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007184 SMAD protein import into nucleus
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
GO:0005769 early endosome
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
KEGG
Endocytosis pathway
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
TGF-beta receptor signaling
Cross-References
SwissProt O95405
TrEMBL
UniProt Splice Variant
Entrez Gene 9372
UniGene Hs.532345
RefSeq NM_004799 NM_007324
HUGO HGNC:6775
OMIM 603755
CCDS CCDS563 CCDS564
HPRD 04782
IMGT
EMBL AC105754 AF104304 AF130419 AF130420 AL513218 BC032680 CH471059
GenPept AAC99462 AAD31694 AAD31695 AAH32680 CAI12285 CAI12286 EAX06790 EAX06791
RNA Seq Atlas 9372