Homo sapiens Gene: PARK2
InnateDB Gene IDBG-98830.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARK2
Gene Name parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Synonyms AR-JP; LPRS2; PDJ; PRKN;
Species Homo sapiens
Ensembl Gene ENSG00000185345
Encoded Proteins
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkin RBR E3 ubiquitin protein ligase
parkin RBR E3 ubiquitin protein ligase
parkin RBR E3 ubiquitin protein ligase
parkin RBR E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
PARK2 was recently shown to promote the clearance of impaired mitochondria by autophagy, termed mitophagy; PARK2 promotes mitophagy by catalyzing mitochondrial ubiquitination, which in turn recruits ubiquitin-binding autophagy components, HDAC6 and p62, leading to mitochondrial clearance.
PARK2 is important for innate defence against M. tuberculosis for having a role in ubiquitin-mediated autophagy of M. tuberculosis
Entrez Gene
Summary The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:161347420-162727771
Strand Reverse strand
Band q26
ENST00000366898 ENSP00000355865
ENST00000366897 ENSP00000355863
ENST00000366896 ENSP00000355862
ENST00000338468 ENSP00000343589
ENST00000366894 ENSP00000355860
ENST00000366892 ENSP00000355858
ENST00000479615 ENSP00000434414
ENST00000612485 ENSP00000480716
ENST00000612540 ENSP00000478353
ENST00000615065 ENSP00000484112
ENST00000610470 ENSP00000483773
Number of Interactions This gene and/or its encoded proteins are associated with 456 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 456 [view]
Protein-Protein 453 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0043130 ubiquitin binding
GO:0051087 chaperone binding
GO:0061630 ubiquitin protein ligase activity
GO:1990381 ubiquitin-specific protease binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0000422 mitochondrion degradation
GO:0001933 negative regulation of protein phosphorylation
GO:0001963 synaptic transmission, dopaminergic
GO:0001964 startle response
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0007417 central nervous system development
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0008219 cell death
GO:0008344 adult locomotory behavior
GO:0010506 regulation of autophagy
GO:0016567 protein ubiquitination
GO:0019538 protein metabolic process
GO:0032232 negative regulation of actin filament bundle assembly
GO:0033132 negative regulation of glucokinase activity
GO:0035249 synaptic transmission, glutamatergic
GO:0042415 norepinephrine metabolic process
GO:0042417 dopamine metabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044257 cellular protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0046676 negative regulation of insulin secretion
GO:0046928 regulation of neurotransmitter secretion
GO:0050804 regulation of synaptic transmission
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051865 protein autoubiquitination
GO:0060548 negative regulation of cell death
GO:0070534 protein K63-linked ubiquitination
GO:0070842 aggresome assembly
GO:0070936 protein K48-linked ubiquitination
GO:0070997 neuron death
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1901215 negative regulation of neuron death
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016235 aggresome
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
Parkinson's disease pathway
Alpha-synuclein and parkin-mediated proteolysis in parkinson`s disease [Biocarta view]
Role of parkin in ubiquitin-proteasomal pathway [Biocarta view]
Alpha-synuclein signaling
UniProt Splice Variant
Entrez Gene 5071
UniGene Hs.132954
RefSeq NM_004562 NM_013987 NM_013988
OMIM 602544
HPRD 03967
EMBL AL008631 AL035697 AL078583 AL132982 AL138716 AL445215 AP000886 AP000887 AP000888 AP001576 AP001577 AP001578 AP002091 AP003699 AY463003 AY564223 AY745247 DQ019286
GenPept AAR27057 AAS88420 AAU93632 AAY85310
RNA Seq Atlas 5071