Homo sapiens Gene: GFRA2
Summary
InnateDB Gene IDBG-9892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFRA2
Gene Name GDNF family receptor alpha 2
Synonyms GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2;
Species Homo sapiens
Ensembl Gene ENSG00000168546
Encoded Proteins
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:21690403-21812357
Strand Reverse strand
Band p21.3
Transcripts
ENST00000306793 ENSP00000306654
ENST00000524240 ENSP00000428518
ENST00000517328 ENSP00000429445
ENST00000518077 ENSP00000429206
ENST00000517892 ENSP00000429979
ENST00000522071 ENSP00000428721
ENST00000519195 ENSP00000430622
ENST00000520676
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016167 glial cell-derived neurotrophic factor receptor activity
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
GO:0031953 negative regulation of protein autophosphorylation
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0019898 extrinsic component of membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
NCAM1 interactions pathway
Axon guidance pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.441202 Hs.720276
RefSeq NM_001165038 NM_001165039 NM_001495 XM_005273472 XM_005273473 XM_005273474 XM_005273475 XM_006716326 XM_006716327
HUGO
OMIM
CCDS CCDS47816 CCDS55207
HPRD 11801
IMGT
EMBL
GenPept
RNA Seq Atlas