InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKAA2

Summary

InnateDB Gene

IDBG-99136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAA2

Gene Name

protein kinase, AMP-activated, alpha 2 catalytic subunit

Synonyms

AMPK; AMPK2; AMPKa2; PRKAA

Species

Homo sapiens

Ensembl Gene

ENSG00000162409

Encoded Proteins

IDBP-99138

protein kinase, AMP-activated, alpha 2 catalytic subunit

IDBP-812957

protein kinase, AMP-activated, alpha 2 catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:56645322-56715335

Strand

Forward strand

Band

p32.2

Transcripts

ENST00000371244	ENSP00000360290
ENST00000610361	ENSP00000481378

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	59 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004679	AMP-activated protein kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035174	histone serine kinase activity
GO:0046872	metal ion binding
GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0050405	[acetyl-CoA carboxylase] kinase activity

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0006853	carnitine shuttle
GO:0006914	autophagy
GO:0006950	response to stress
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0008610	lipid biosynthetic process
GO:0010508	positive regulation of autophagy
GO:0016055	Wnt signaling pathway
GO:0031669	cellular response to nutrient levels
GO:0032007	negative regulation of TOR signaling
GO:0035404	histone-serine phosphorylation
GO:0042149	cellular response to glucose starvation
GO:0042304	regulation of fatty acid biosynthetic process
GO:0042593	glucose homeostasis
GO:0042752	regulation of circadian rhythm
GO:0043066	negative regulation of apoptotic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045821	positive regulation of glycolytic process
GO:0048511	rhythmic process
GO:0055089	fatty acid homeostasis
GO:0061024	membrane organization
GO:2000505	regulation of energy homeostasis