Homo sapiens Gene: TM2D1
Summary
InnateDB Gene IDBG-99316.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TM2D1
Gene Name TM2 domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162604
Encoded Proteins
TM2 domain containing 1
TM2 domain containing 1
TM2 domain containing 1
TM2 domain containing 1
TM2 domain containing 1
TM2 domain containing 1
TM2 domain containing 1
TM2 domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:61681046-61725423
Strand Reverse strand
Band p31.3
Transcripts
ENST00000371180 ENSP00000360222
ENST00000294613 ENSP00000294613
ENST00000371178
ENST00000371177 ENSP00000475297
ENST00000472357
ENST00000488206 ENSP00000476178
ENST00000472989
ENST00000488410
ENST00000468586 ENSP00000475186
ENST00000494926 ENSP00000475844
ENST00000496465 ENSP00000475529
ENST00000606498 ENSP00000475700
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0006915 apoptotic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 83941
UniGene
RefSeq NM_032027
HUGO HGNC:24142
OMIM 610080
CCDS CCDS65554
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 83941