Homo sapiens Gene: IL12RB2
Summary
InnateDB Gene IDBG-99563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL12RB2
Gene Name interleukin 12 receptor, beta 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000081985
Encoded Proteins
interleukin 12 receptor, beta 2
interleukin 12 receptor, beta 2
interleukin 12 receptor, beta 2
interleukin 12 receptor, beta 2
interleukin 12 receptor, beta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn\'s disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:67307364-67396900
Strand Forward strand
Band p31.3
Transcripts
ENST00000262345 ENSP00000262345
ENST00000371000 ENSP00000360039
ENST00000441640 ENSP00000400959
ENST00000465396
ENST00000544434 ENSP00000442443
ENST00000541374 ENSP00000445276
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032609 interferon-gamma production
GO:0032729 positive regulation of interferon-gamma production
GO:0034097 response to cytokine
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
IL-12 signaling pathway
PID BIOCARTA
No2-dependent il-12 pathway in nk cells [Biocarta view]
Il12 and stat4 dependent signaling pathway in th1 development [Biocarta view]
PID NCI
IL27-mediated signaling events
IL12-mediated signaling events
Cross-References
SwissProt Q99665
TrEMBL
UniProt Splice Variant
Entrez Gene 3595
UniGene
RefSeq NM_001258216 NM_001559 NM_001258214 NM_001258215 XM_005270825 XM_005270827 XM_005270828 XM_006710617
HUGO HGNC:5972
OMIM 601642
CCDS CCDS72805 CCDS638 CCDS58006 CCDS58007
HPRD 03383
IMGT
EMBL AL358512 AL389925 AY640177 BC104772 BC104774 BC143249 CH471059 U64198
GenPept AAB36675 AAI04773 AAI04775 AAI43250 AAT45456 CAH69960 CAH70407 EAX06499
RNA Seq Atlas 3595