InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SORD

Summary

InnateDB Protein

IDBP-10007.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SORD

Protein Name

sorbitol dehydrogenase

Synonyms

HEL-S-95n; SORD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000267814

InnateDB Gene

IDBG-10005 (SORD)

Protein Structure

UniProt Annotation

Function

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane; Peripheral membrane protein. Cell projection, cilium, flagellum. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level). {ECO:0000269PubMed:16278369, ECO:0000269PubMed:19423711, ECO:0000269PubMed:20372835}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003939	L-iditol 2-dehydrogenase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0030246	carbohydrate binding
GO:0051287	NAD binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006060	sorbitol metabolic process
GO:0006062	sorbitol catabolic process
GO:0030317	sperm motility
GO:0046370	fructose biosynthetic process
GO:0051160	L-xylitol catabolic process
GO:0051164	L-xylitol metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0031514	motile cilium
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q00796