Homo sapiens Protein: PKN2 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-100137.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | PKN2 | ||||||||||||||||||||||||||
Protein Name | protein kinase N2 | ||||||||||||||||||||||||||
Synonyms | Pak-2; PAK2; PRK2; PRKCL2; PRO2042; STK7; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000359544 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-100129 (PKN2) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c- fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269PubMed:10226025, ECO:0000269PubMed:10926925, ECO:0000269PubMed:11777936, ECO:0000269PubMed:11781095, ECO:0000269PubMed:15364941, ECO:0000269PubMed:17332740, ECO:0000269PubMed:20188095, ECO:0000269PubMed:20974804, ECO:0000269PubMed:21754995, ECO:0000269PubMed:9121475}. | ||||||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Nucleus. Membrane {ECO:0000250}. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. | ||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||
Tissue Specificity | Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells. {ECO:0000269PubMed:10026169, ECO:0000269PubMed:21754995}. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR000961 AGC-kinase, C-terminal IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR011072 HR1 rho-binding repeat IPR017892 Protein kinase, C-terminal IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 PF02185 PF00433 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||||||
SMART |
SM00133
SM00220 SM00742 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | Q16513 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q16513 | ||||||||||||||||||||||||||
TrEMBL | Q6P5W9 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 5586 | ||||||||||||||||||||||||||
UniGene | Hs.703016 | ||||||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||||||
HUGO | HGNC:9406 | ||||||||||||||||||||||||||
OMIM | 602549 | ||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | 03972 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AC119426 AK298595 AK300304 AK301066 AL136381 BC062620 BC125199 CH471097 S75548 U33052 | ||||||||||||||||||||||||||
GenPept | AAB33346 AAC50208 AAH62620 AAI25200 BAG60783 BAG62057 BAG62673 CAI23271 EAW73161 EAW73164 | ||||||||||||||||||||||||||