Version 5.4
Homo sapiens Protein: GBP3
Summary
InnateDB Protein IDBP-100160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBP3
Protein Name guanylate binding protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359512
InnateDB Gene IDBG-100156 (GBP3)
Protein Structure
UniProt Annotation
Function Exhibits antiviral activity against influenza virus. {ECO:0000269PubMed:22106366}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17266443}. Membrane {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF02841
PF02263
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0R5
PhosphoSite PhosphoSite-Q9H0R5
TrEMBL H3BPH2
UniProt Splice Variant
Entrez Gene 2635
UniGene Hs.720167
RefSeq NP_060754
HUGO HGNC:4184
OMIM 600413
CCDS CCDS717
HPRD 02683
IMGT
EMBL AL136680 AL139416 AL160008 BC017992 BC140837 CH471097 JF927951
GenPept AAH17992 AAI40838 AEI54565 CAB66615 CAI21697 CAI22970 CAM28262 CAM28327 EAW73151 EAW73153

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca