InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FNBP1L

Summary

InnateDB Protein

IDBP-100342.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FNBP1L

Protein Name

formin binding protein 1-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000260506

InnateDB Gene

IDBG-100334 (FNBP1L)

Protein Structure

UniProt Annotation

Function

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269PubMed:15260990, ECO:0000269PubMed:16326391, ECO:0000269PubMed:19342671}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16757518}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0006900	membrane budding
GO:0006914	autophagy
GO:0007165	signal transduction
GO:0010324	membrane invagination
GO:0016050	vesicle organization
GO:0030050	vesicle transport along actin filament
GO:0051491	positive regulation of filopodium assembly
GO:0072583	clathrin-mediated endocytosis
GO:0097320	membrane tubulation

Cellular Component

GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0070062	extracellular vesicular exosome