Version 5.4
Homo sapiens Protein: PTBP2
Summary
InnateDB Protein IDBP-100412.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTBP2
Protein Name polypyrimidine tract binding protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359216
InnateDB Gene IDBG-100408 (PTBP2)
Protein Structure
UniProt Annotation
Function RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. {ECO:0000269PubMed:11003644, ECO:0000269PubMed:12667457}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non- neuronal tissues. {ECO:0000269PubMed:11003644, ECO:0000269PubMed:12213192}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006376 mRNA splice site selection
GO:0006397 mRNA processing
GO:0033119 negative regulation of RNA splicing
GO:2000177 regulation of neural precursor cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR006536 HnRNP-L/PTB/hephaestus splicing factor
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKA9
PhosphoSite PhosphoSite-Q9UKA9
TrEMBL O95652
UniProt Splice Variant
Entrez Gene 58155
UniGene Hs.743449
RefSeq NP_001287916
HUGO HGNC:17662
OMIM 608449
CCDS CCDS72828
HPRD 12233
IMGT
EMBL AB051232 AB051233 AF176085 AF530580 AF530581 AF530582 AF530583 AK299755 AL357150 BC016582 BK000526 U89241
GenPept AAD09652 AAF14284 AAH16582 AAM94624 AAM94625 AAM94626 AAM94627 BAB71742 BAB71743 BAG61644 CAH70266 CAH70267 CAH70268 CAH70269 DAA00060

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca