InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPYD

Summary

InnateDB Protein

IDBP-100419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPYD

Protein Name

dihydropyrimidine dehydrogenase

Synonyms

DHP; DHPDHASE; DPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000359211

InnateDB Gene

IDBG-100417 (DPYD)

Protein Structure

UniProt Annotation

Function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

Subcellular Localization

Cytoplasm.

Disease Associations

Dihydropyrimidine dehydrogenase deficiency (DPYDD) [MIM:274270]: A metabolic disorder with large phenotypic variability, ranging from no symptoms to a convulsive disorder with motor and mental retardation. It is characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5- fluorouracil. {ECO:0000269PubMed:14702039, ECO:0000269PubMed:16710414, ECO:0000269PubMed:9266349, ECO:0000269PubMed:9439663}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004152	dihydroorotate dehydrogenase activity
GO:0004158	dihydroorotate oxidase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
GO:0017150	tRNA dihydrouridine synthase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006145	purine nucleobase catabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006208	pyrimidine nucleobase catabolic process
GO:0006210	thymine catabolic process
GO:0006212	uracil catabolic process
GO:0006214	thymidine catabolic process
GO:0006222	UMP biosynthetic process
GO:0008033	tRNA processing
GO:0019483	beta-alanine biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001269 tRNA-dihydrouridine synthase
IPR005720 Dihydroorotate dehydrogenase domain
IPR009051 Alpha-helical ferredoxin
IPR012135 Dihydroorotate dehydrogenase, class 1/ 2
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF01207
PF01180
PF07992

PRINTS

PR00368

PIRSF

PIRSF006621
PIRSF000164

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt