InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VCAM1

Summary

InnateDB Protein

IDBP-100529.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VCAM1

Protein Name

vascular cell adhesion molecule 1

Synonyms

CD106; INCAM-100;

Species

Homo sapiens

Ensembl Protein

ENSP00000304611

InnateDB Gene

IDBG-100525 (VCAM1)

Protein Structure

UniProt Annotation

Function

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 451 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	451 [view]
Protein-Protein	444 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008131	primary amine oxidase activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0009308	amine metabolic process
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0022614	membrane to membrane docking
GO:0030183	B cell differentiation
GO:0030198	extracellular matrix organization
GO:0042102	positive regulation of T cell proliferation
GO:0050776	regulation of immune response
GO:0050901	leukocyte tethering or rolling
GO:0055114	oxidation-reduction process
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0002102	podosome
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030175	filopodium
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome
GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
IPR003989 Vascular cell adhesion molecule-1
IPR007110 Immunoglobulin-like domain
IPR008424 Immunoglobulin C2-set
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF05790
PF07679
PF00047

PRINTS

PR01472
PR01474

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt