InnateDB Protein
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IDBP-10061.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZFYVE26
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Protein Name
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zinc finger, FYVE domain containing 26
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Synonyms
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FYVE-CENT; SPG15;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000251119
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InnateDB Gene
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IDBG-10059 (ZFYVE26)
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Protein Structure
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Function |
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269PubMed:20208530}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20208530}. Midbody {ECO:0000269PubMed:20208530}. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.
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Disease Associations |
Spastic paraplegia 15, autosomal recessive (SPG15) [MIM:270700]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration. {ECO:0000269PubMed:18394578, ECO:0000269PubMed:19084844, ECO:0000269PubMed:19805727}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. {ECO:0000269PubMed:18394578}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000306
FYVE zinc finger
IPR011011
Zinc finger, FYVE/PHD-type
IPR017455
Zinc finger, FYVE-related
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PFAM |
PF01363
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PRINTS |
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PIRSF |
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SMART |
SM00064
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TIGRFAMs |
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Modification |
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SwissProt |
Q68DK2
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PhosphoSite |
PhosphoSite-Q68DK2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23503
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UniGene |
Hs.98041
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RefSeq |
NP_056161
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HUGO |
HGNC:20761
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OMIM |
612012
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CCDS |
CCDS9788
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HPRD |
15734
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IMGT |
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EMBL |
AB002319
AB425197
AK128496
AK304428
AL049779
AL121595
BC033235
BX537886
BX538025
BX648683
CH471061
CR749276
CR749365
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GenPept |
AAH33235
BAA20779
BAC87467
BAG11658
BAG65255
CAD97882
CAD97971
CAH10379
CAH18131
CAH18218
EAW80954
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